Laboratory of Data Discovery for Health (D²4H)

Research Teams

Featured Publications

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The Laboratory of Data Discovery for Health (D²4H) sets to play pivotal role in gathering and curating massive, unique data resources and developing new, deep, frontier analytics for protecting global public health and improving individual healthcare through precision medicine.

The Laboratory of Data Discovery for Health (D²4H) sets to play pivotal role in gathering and curating massive, unique data resources and developing new, deep, frontier analytics for protecting global public health and improving individual healthcare through precision medicine.

Featured Publications

Programme 1

AI-Enhanced Global and Personal Health Protection

Associations of Serum Lipid Traits With Fracture and Osteoporosis: A Prospective Cohort Study From the UK Biobank
- Journal of Cachexia, Sarcopenia and Muscle

29 Oct 2024
Comparing role of religion in perception of the COVID-19 vaccines in Africa and Asia Pacific
- Communications Medicine

24 Oct 2024
Association Between Oral Fluoroquinolones and Neuropsychiatric Events: Self-Controlled Case Series With Active Comparator Design.
- Pharmacoepidemiology and Drug Safety

17 Oct 2024
Exploring Offline Large Language Models for Clinical Information Extraction: A Study of Renal Histopathological Reports of Lupus Nephritis Patients
- Studies in Health Technology and Informatics

22 Aug 2024
Social Vulnerability and Compliance With World Health Organization Advice on Protective Behaviors Against COVID-19 in African and Asia Pacific Countries: Factor Analysis to Develop a Social Vulnerability Index
- JMIR Public Health and Surveillance

13 Aug 2024
A Prediction Model for Identifying Seasonal Influenza Vaccination Uptake Among Children in Wuxi, China: Prospective Observational Study
- JMIR Public Health and Surveillance

17 Jun 2024
Effectiveness of nirmatrelvir/ritonavir in children and adolescents aged 12-17 years following SARS-CoV-2 Omicron infection: A target trial emulation
- Nature Communications

08 Jun 2024
Increased incidence of invasive pneumococcal disease in Hong Kong in 2023
- Journal of Infection

11 May 2024
Wastewater Surveillance Provides Spatiotemporal SARS-CoV-2 Infection Dynamics
- Engineering

15 Mar 2024
Perceptions about respiratory syncytial virus (RSV) and attitudes toward the RSV vaccine among the general public in China: A cross-sectional survey
- Human Vaccines & Immunotherapeutics

18 Feb 2024
Estimating the Epidemic Size of Superspreading Coronavirus Outbreaks in Real Time: Quantitative Study
- JMIR Public Health and Surveillance

12 Feb 2024
COVID-19 vaccine acceptance and its associated factors in the Western Pacific Region
- The Lancet Regional Health - Western Pacific

12 Feb 2024
A comparison of cardiovascular disease, cancer, mortality, and Graves' ophthalmopathy following treatment for hyperthyroidism: A Bayesian network meta‐analysis
- World J Surg

18 Jan 2024
Generative artificial intelligence can have a role in combating vaccine hesitancy
- BMJ

16 Jan 2024
Optimal timing of nirmatrelvir/ritonavir treatment after COVID-19 symptom onset or diagnosis: target trial emulation
- Nature Communications

16 Dec 2023
Vaccine confidence mediates the association between a pro-social pay-it-forward intervention and improved influenza vaccine uptake in China: A mediation analysis
- Vaccine

15 Dec 2023
Substantial Disparities In COVID-19 Vaccine Uptake And Unmet Immunization Demand In Low- And Middle-Income Countries
- Health Affairs

01 Dec 2023
Who gets COVID-19 booster vaccination? Trust in public health institutions and promotion strategies post-pandemic in the Republic of Korea
- Vaccine

15 Nov 2023
Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulation
- Nature Medicine

01 Nov 2023
Navigating a rapidly changing information and communication landscape amidst “infodemics”
- Modernizing Global Health Security to Prevent, Detect, and Respond

20 Oct 2023
Cervical screening among Chinese females in the era of HPV vaccination: a population-based survey on screening uptake and regular screening following an 18-year organized screening program
- Journal of Gynecologic Oncology

18 Oct 2023
Cost-effectiveness of seasonal influenza vaccination of children in China: a modeling analysis
- Infectious Diseases of Poverty

11 Oct 2023
Conversational AI and Vaccine Communication: Systematic Review of the Evidence
- Journal of Medical Internet Research

03 Oct 2023
The impact of a complex school nutrition intervention on double burden of malnutrition among Thai primary school children: a 2-year quasi-experiment
- Public Health

19 Sep 2023
“I have taken your izzath (honour), so you can’t betray me”: Young people’s lived experiences of navigating sexual norms and violence in Bangladesh
- Cogent Public Health

06 Sep 2023
Dissecting human population variation in single-cell responses to SARS-CoV-2
- Nature

09 Aug 2023
Recent trends in vaccine coverage and confidence: A cause for concern
- Human Vaccines & Immunotherapeutics

01 Aug 2023
Effectiveness of chatbots on COVID vaccine confidence and acceptance in Thailand, Hong Kong, and Singapore
- npj Digital Medicine

25 May 2023
Global antimicrobial-resistance drivers: an ecological country-level study at the human–animal interface
- The Lancet Planetary Health

01 Apr 2023
Willingness to Vaccinate Against Herpes Zoster and Its Associated Factors Across WHO Regions: Global Systematic Review and Meta-Analysis
- JMIR Public Health and Surveillance

09 Mar 2023
Battle of Polio eradication in the Western Pacific Region in the transition to COVID-19 endemicity
- Journal of Infection

21 Feb 2023
Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study
- The Lancet Infectious Diseases

13 Feb 2023
Maximizing the cost-effectiveness of cervical screening in the context of routine HPV vaccination by optimizing screening strategies with respect to vaccine uptake: a modeling analysis
- BMC Medicine

10 Feb 2023
The emerging antimicrobial resistance crisis during the COVID-19 surge in China
- The Lancet Microbe

10 Feb 2023
Applications of Social Media and Digital Technologies in COVID-19 Vaccination: Scoping Review
- Journal of Medical Internet Research

10 Feb 2023
Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population
- Nature Medicine

18 Jan 2023
Estimating the transmission dynamics of SARS-CoV-2 Omicron BF.7 in Beijing after adjustment of the zero-COVID policy in November–December 2022
- Nature Medicine

13 Jan 2023
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong's omicron BA.2 wave: a retrospective cohort study
- The Lancet Infectious Diseases

24 Aug 2022
Geographic social inequalities in information-seeking response to the COVID-19 pandemic in China: longitudinal analysis of Baidu Index
- Scientific Reports

28 Jul 2022
Vaccines and the social amplification of risk
- Risk Analysis

14 May 2022
Changes in Parental Attitudes Toward COVID-19 Vaccination and Routine Childhood Vaccination During the COVID-19 Pandemic: Repeated Cross-sectional Survey Study
- JMIR Public Health and Surveillance

13 May 2022
Nonbiomedical factors affecting antibiotic use in the community: authors' response
- Clinical Microbiology and Infection

09 Mar 2022
An occupational risk of hepatitis E virus infection in the workers along the meat supply chains in Guangzhou, China
- One Health

28 Feb 2022
The allocation of COVID-19 vaccines and antivirals against emerging SARS-CoV-2 variants of concern in East Asia and Pacific region: A modelling study
- The Lancet Regional Health, Western Pacific

02 Feb 2022
Herpes zoster related hospitalization after inactivated (CoronaVac) and mRNA (BNT162b2) SARS-CoV-2 vaccination: A self-controlled case series and nested case-control study (jointly published by Programme 1 & 4)
- The Lancet Regional Health Western Pacific

01 Feb 2022
Impacts of School Nutrition Interventions on the Nutritional Status of School-Aged Children in Asia: A Systematic Review and Meta-Analysis
- Nutrients

28 Jan 2022
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination
- Nature Medicine

20 Jan 2022
Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
- Eurosurveillance

13 Jan 2022
Estimating the transmission advantage of the D614G mutant strain of SARS-CoV-2, December 2019 to June 2020
- Eurosurveillance

09 Dec 2021
Delays in routine childhood vaccinations and their relationship with parental vaccine hesitancy: a cross-sectional study in Wuxi, China
- Expert Review of Vaccines

26 Nov 2021
A global assessment of the impact of school closure in reducing COVID-19 spread
- Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

22 Nov 2021
Non-biomedical factors affecting antibiotic use in the community: a mixed-methods systematic review and meta-analysis
- Clinical Microbiology and Infection

09 Nov 2021
Cost-effectiveness of strategies for preventing paediatric lower respiratory infections associated with respiratory syncytial virus in eight Chinese cities
- Vaccine

26 Aug 2021
Public Attitudes and Factors of COVID-19 Testing Hesitancy in the United Kingdom and China: Comparative Infodemiology Study
- JMIR Infodemiology

22 Aug 2021
Effects of adjusting public health, travel, and social measures during the roll-out of COVID-19 vaccination: a modelling study
- The Lancet Public Health

10 Aug 2021
Economic evaluation of varicella vaccination strategies in Jiangsu province, China: a decision-tree Markov model
- Human Vaccines & Immunotherapeutics

06 Aug 2021
Factors related to perceived stress during the COVID-19 epidemic context among the general population in China: A cross-sectional nationwide study
- Journal of Affective Disorders

29 Jul 2021
Vaccination against COVID-19: A systematic review and meta-analysis of acceptability and its predictors
- Preventive Medicine

22 Jun 2021
Assessing COVID-19 Vaccine Hesitancy, Confidence, and Public Engagement: A Global Social Listening Study
- Journal of Medical Internet Research

11 Jun 2021
Using risk stratification to optimize mammography screening in Chinese women
- JNCI Cancer Spectrum

07 Jun 2021
Cost-effectiveness analysis of the nonavalent human papillomavirus vaccine for the prevention of cervical cancer in Singapore
- Vaccine

18 Mar 2021
Nowcasting epidemics of novel pathogens: lessons from COVID-19 (jointly published by Programme 1 & 2)
- Nature Medicine

15 Mar 2021
Real-time tracking and prediction of COVID-19 infection using digital proxies of population mobility and mixing
- Nature Communications

08 Mar 2021
Quantifying the uncertainty of CovidSim
- Nature Computational Science

22 Feb 2021
Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera
- Journal of Clinical Microbiology

21 Jan 2021
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020 (jointly published by Programme 1 & 2)
- Eurosurveillance

07 Jan 2021

Programme 2

AI-Metagenomic Platform to Identify Emerging Pathogens

Using artificial intelligence to document the hidden RNA virosphere
- Cell

09 Oct 2024
VirID: Beyond Virus Discovery—An Integrated Platform for Comprehensive RNA Virus Characterization, Molecular Biology and Evolution
- Molecular Biology and Evolution

27 Sep 2024
Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic
- Cell

19 Sep 2024
Virology—The next fifty years
- Perspective

19 Sep 2024
Evolutionary characterization of the establishment of H6 influenza viruses in domestic geese in China: implications for the position of the host in the ecosystem
- Virus Evolution

14 Sep 2024
Farmed fur animals harbour viruses with zoonotic spillover potential
- Nature

04 Sep 2024
Five-year longitudinal surveillance reveals the continual circulation of both alpha- and beta-coronaviruses in Plateau and Gansu pikas (Ochotona spp.) at Qinghai Lake, China
- Emerging Microbes & Infections

24 Aug 2024
Analysis of the genetic diversity in RNA-directed RNA polymerase sequences: implications for an automated RNA virus classification system
- Virus Evolution

25 Jul 2024
A ~40-kb flavi-like virus does not encode a known error-correcting mechanism
- Proceedings of the National Academy of Sciences

17 Jul 2024
Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease
- mSphere

16 Jul 2024
Genomic and phylogenetic features of the Picobirnaviridae suggest microbial rather than animal hosts
- Virus Evolution

22 Apr 2024
The clinical outcome of COVID-19 is strongly associated with microbiome dynamics in the upper respiratory tract
- Journal of Infection

09 Feb 2024
Evidence for an ancient aquatic origin of the RNA viral order Articulavirales
- Proceedings of the National Academy of Sciences (PNAS)

31 Oct 2023
Divergent hepaciviruses, delta-like viruses, and a chu-like virus in Australian marsupial carnivores (dasyurids)
- Virus Evolution

14 Oct 2023
Host traits shape virome composition and virus transmission in wild small mammals
- Cell

12 Oct 2023
Newly identified lineages of porcine hemagglutinating encephalomyelitis virus exhibit respiratory phenotype
- Virus Evolution

18 Aug 2023
Longitudinal monitoring reveals the emergence and spread of blaGES-5-harboring carbapenem-resistant Klebsiella quasipneumoniae in a Hong Kong hospital wastewater discharge line
- Science of The Total Environment

16 Aug 2023
Expanding the range of the respiratory infectome in Australian feedlot cattle with and without respiratory disease using metatranscriptomics
- Microbiome

25 Jul 2023
Gammaretroviruses, novel viruses and pathogenic bacteria in Australian bats with neurological signs, pneumonia and skin lesions
- Virology

17 Jul 2023
Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential
- Nature Communications

10 Jul 2023
Characterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health
- Journal of Virology

08 Jun 2023
Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins
- PLoS Pathogens

17 May 2023
Global environmental resistome: Distinction and connectivity across diverse habitats benchmarked by metagenomic analyses
- Water Research

15 May 2023
Probable airborne transmission of Burkholderia pseudomallei causing an urban outbreak of melioidosis during typhoon season in Hong Kong, China
- Emerging Microbes & Infections

01 May 2023
Evaluation of Mycobacterium tuberculosis enrichment in metagenomic samples using ONT adaptive sequencing and amplicon sequencing for identification and variant calling
- Scientific Reports

31 Mar 2023
New insights into the impact of microbiome on horizontal and vertical transmission of a tick-borne pathogen
- Microbiome

14 Mar 2023
Substantial viral and bacterial diversity at the bat–tick interface
- Microbial Genomics

02 Mar 2023
Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
- Nature Microbiology

05 Jan 2023
Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b in Wild Birds and Live Bird Markets, Egypt
- Pathogens

26 Dec 2022
Unlocking capacities of genomics for the COVID-19 response and future pandemics
- Nature Methods

08 Apr 2022
Nowcasting epidemics of novel pathogens: lessons from COVID-19 (jointly published by Programme 1 & 2)
- Nature Medicine

15 Mar 2021
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020 (jointly published by Programme 1 & 2)
- Eurosurveillance

07 Jan 2021

Programme 3

AI-Enabled Causal Inference for Disease Control

Evaluating the impact of extended dosing intervals on mRNA COVID-19 vaccine effectiveness in adolescents
- BMC Medicine

12 Sep 2024
Efficacy and safety of respiratory syncytial virus prefusion F protein vaccines in adults
- Journal of Infection

01 Aug 2024
Forecasting of influenza activity and associated hospital admission burden and estimating the impact of COVID-19 pandemic on 2019/20 winter season in Hong Kong
- PLoS Computational Biology

31 Jul 2024
Predicting Efficacies of Fractional Doses of Vaccines by Using Neutralizing Antibody Levels: Systematic Review and Meta-Analysis
- JMIR Public Health and Surveillance

12 Jul 2024
Editorial: Impact of public health and social measures for COVID-19 control on infectious disease epidemiology
- Frontiers in Public Health

09 Jul 2024
Prior infections and effectiveness of SARS-CoV-2 vaccine in test-negative studies: A systematic review and meta-analysis
- American Journal of Epidemiology

24 Jun 2024
Effectiveness of nirmatrelvir/ritonavir and molnupiravir in non-hospitalized adults with COVID-19: systematic review and meta-analysis of observational studies
- Journal of Antimicrobial Chemotherapy

05 May 2024
Global Seasonal Activities of Respiratory Syncytial Virus Before the Coronavirus Disease 2019 Pandemic: A Systematic Review
- Open Forum Infectious Diseases

25 Apr 2024
A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients
- eLife

16 Apr 2024
Comparative epidemiology of outbreaks caused by SARS-CoV-2 Delta and Omicron variants in China
- Epidemiology and Infection

19 Mar 2024
Effectiveness of mRNA BNT162b2 and inactivated CoronaVac vaccines against severe COVID-19 outcomes among non-hospitalised children aged 1-3 years with SARS-CoV-2 Omicron infection
- International Journal of Antimicrobial Agents

23 Jan 2024
Public Health Impact of Paxlovid as Treatment for COVID-19, United States
- Emerging Infectious Diseases

05 Jan 2024
Nowcasting and Forecasting Seasonal Influenza Epidemics - China, 2022-2023
- China CDC Weekly

08 Dec 2023
Mitigation of respiratory syncytial virus epidemics by RSVpreF vaccines after the COVID-19 pandemic in the UK: a modelling study
- The Lancet

01 Nov 2023
Comparison of Bivalent and Monovalent mRNA Vaccine Boosters
- Clinical Infectious Diseases

30 Aug 2023
Estimate of COVID-19 Deaths, China, December 2022–February 2023
- EID Journal

28 Aug 2023
The need for a clinical case definition in test-negative design studies estimating vaccine effectiveness
- NPJ Vaccines

12 Aug 2023
Residential Clustering of Coronavirus Disease 2019 Cases and Efficiency of Building-Wide Compulsory Testing Notices as a Transmission Control Measure in Hong Kong
- The Journal of Infectious Diseases

24 Apr 2023
The effect of variation of individual infectiousness on SARS-CoV-2 transmission in households
- eLife

07 Mar 2023
Inferring time-varying generation time, serial interval, and incubation period distributions for COVID-19
- Nature Communications

10 Jan 2023
Nonpharmaceutical interventions for managing SARS-CoV-2
- Current Opinion in Pulmonary Medicine

01 May 2023
Accounting for the Potential of Overdispersion in Estimation of the Time-varying Reproduction Number
- Epidemiology

01 Mar 2023
Cost effectiveness of fractional doses of COVID-19 vaccine boosters in India
- Med

12 Feb 2023
Characterizing Human Collective Behaviors During COVID-19 - Hong Kong SAR, China, 2020
- China CDC Weekly

27 Jan 2023
Association Between Population-Level Factors and Household Secondary Attack Rate of SARS-CoV-2: A Systematic Review and Meta-analysis
- Open Forum Infectious Diseases

16 Dec 2022
Hospitalizations and mortality during the first year of the COVID-19 pandemic in Hong Kong, China: An observational study
- The Lancet Regional Health Western Pacific

23 Nov 2022
Epidemic Surveillance of Influenza Infections: A Network-Free Strategy - Hong Kong Special Administrative Region, China, 2008-2011
- China CDC Weekly

18 Nov 2022
Prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic: a modelling study
- The Lancet Global Health

01 Nov 2022
Immunogenicity, efficacy, and safety of SARS-CoV-2 vaccine dose fractionation: a systematic review and meta-analysis
- BMC Medicine

25 Oct 2022
Travel-related Importation and Exportation Risks of SARS-CoV-2 Omicron Variant in 367 Prefectures (Cities) - China, 2022
- China CDC Weekly

07 Oct 2022
Impact of mass rapid antigen testing for SARS-CoV-2 to mitigate Omicron outbreaks in China
- Journal of Travel Medicine

24 Sep 2022
Evaluation of Effectiveness of Global COVID-19 Vaccination Campaign
- Emerging Infectious Diseases

09 Sep 2022
Epidemiology of Infections with SARS-CoV-2 Omicron BA.2 Variant, Hong Kong, January–March 2022
- Emerging Infectious Diseases

09 Sep 2022
Effectiveness of CoronaVac and BNT162b2 Vaccines Against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron BA.2 Infections in Hong Kong
- The Journal of Infectious Diseases

02 Sep 2022
Reproduction number of monkeypox in the early stage of the 2022 multi-country outbreak
- Journal of Travel Medicine

25 Aug 2022
Within-host dynamics of SARS-CoV-2 infection: A systematic review and meta-analysis
- Transboundary and Emerging Diseases

30 Jul 2022
Systematic review and meta-analyses of superspreading of SARS-CoV-2 infections
- Transboundary and Emerging Diseases

07 Jul 2022
International risk of SARS-CoV-2 Omicron variant importations originating in South Africa
- Journal of Travel Medicine

15 Jun 2022
Accuracy for key parameters in modelling study
- The Lancet Public Health

01 Jun 2022
Shorter serial intervals and incubation periods in SARS-CoV-2 variants than the SARS-CoV-2 ancestral strain
- Journal of Travel Medicine

20 Apr 2022
Reproduction Number of the Omicron Variant Triples That of the Delta Variant
- Viruses

15 Apr 2022
Optimizing COVID-19 surveillance using historical electronic health records of influenza infections
- PNAS Nexus

14 Apr 2022
Modeling comparative cost-effectiveness of SARS-CoV-2 vaccine dose fractionation in India
- Nature Medicine

24 Feb 2022
Reproduction Numbers of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants: A Systematic Review and Meta-analysis
- Clinical Infectious Diseases

16 Feb 2022
Genomic epidemiology of SARS-CoV-2 under an elimination strategy in Hong Kong
- Nature Communications

08 Feb 2022
Restaurant-Based Measures to Control Community Transmission of COVID-19, Hong Kong
- Emerging Infectious Disease

07 Feb 2022
RiskEstim: A Software Package to Quantify COVID-19 Importation Risk
- Frontiers in Physics

24 Jan 2022
Cost-effective proactive testing strategies during COVID-19 mass vaccination: A modelling study
- The Lancet Regional Health – Americas

15 Jan 2022
Pandemic fatigue and attenuated impact of avoidance behaviours against COVID-19 transmission in Hong Kong by cross-sectional telephone surveys
- BMJ Open

20 Dec 2021
CoronaVac efficacy data from Turkey
- The Lancet

20 Nov 2021
Using secondary cases to characterize the severity of an emerging or re-emerging infection
- Nature Communication

04 Nov 2021
Nowcasting towards sustainable SARS-CoV-2 endemicity
- The Lancet

27 Oct 2021
Effectiveness of International Travel Controls for Delaying Local Outbreaks of COVID-19
- Emerging Infectious Disease

13 Oct 2021
Sepsis-associated hospitalisations and antimicrobial use in Hong Kong
- Epidemiology & Infection

11 Oct 2021
COVID-19 Importation Risk From Olympic Athletes Prior to the Tokyo 2020 Olympics
- Frontiers in Physics

07 Oct 2021
Optimal Timing of Remdesivir Initiation in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Administered With Dexamethasone
- Clinical Infectious Diseases

22 Aug 2021
Joint Estimation of Generation Time and Incubation Period for Coronavirus Disease 2019
- The Journal of Infectious Diseases

21 Aug 2021
The differential importation risks of COVID-19 from inbound travellers and the feasibility of targeted travel controls: A case study in Hong Kong
- The Lancet Regional Health – Western Pacific

13 Aug 2021
COVID-19 transmission in Hong Kong despite universal masking
- Journal of Infection

31 Jul 2021
Assessing Community Vulnerability over 3 Waves of COVID-19 Pandemic, Hong Kong, China
- Emerging Infectious Diseases

27 Jul 2021
Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19
- The Lancet Microbe

16 Jul 2021
Clinical improvement, outcomes, antiviral activity, and costs associated with early treatment with remdesivir for patients with COVID-19
- Clinical Infectious Diseases

15 Jul 2021
Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality
- Nature Medicine

05 Jul 2021
The incubation period distribution of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis
- Clinical Infectious Diseases

12 Jun 2021
Accounting for imported cases in estimating the time-varying reproductive number of COVID-19 in Hong Kong
- The Journal of Infectious Diseases

04 Jun 2021
Risk for International Importations of Variant SARS-CoV-2 Originating in the United Kingdom
- Emerging Infectious Diseases

27 May 2021
Transmission dynamics and control of two epidemic waves of SARS-CoV-2 in South Korea
- BMC Infectious Diseases

26 May 2021
Serial intervals and case isolation delays for COVID-19: a systematic review and meta-analysis
- Clinical Infectious Diseases

26 May 2021
Upper Respiratory Infections in Schools and Childcare Centers Reopening after COVID-19 Dismissals, Hong Kong
- Emerging Infectious Diseases

01 May 2021
Decreased Use of Broad-Spectrum Antibiotics During the Coronavirus Disease 2019 Epidemic in South Korea
- The Journal of Infectious Diseases

15 Apr 2021
Assessing Asymptomatic, Presymptomatic, and Symptomatic Transmission Risk of Severe Acute Respiratory Syndrome Coronavirus 2
- Clinical Infectious Diseases

27 Mar 2021
Clinical outcomes of different therapeutic options for COVID-19 in two Chinese case cohorts: A propensity-score analysis
- EClinicalMedicine

13 Feb 2021
Vaccination Uncertainties and COVID-19 Prospects in 2021
- China CDC Weekly

12 Feb 2021
Changing disparities in COVID-19 burden in the ethnically homogeneous population of Hong Kong through pandemic waves: an observational study
- Clinical Infectious Diseases

06 Jan 2021
Face masks and COVID-19: don't let perfect be the enemy of good
- Euro-surveillance

10 Dec 2020

Programme 4

AI and Pharmaceuticals in Non-Communicable Diseases (NCDs)

Association Between Oral Fluoroquinolones and Neuropsychiatric Events: Self-Controlled Case Series With Active Comparator Design
- Pharmacoepidemiology and Drug Safety

17 Oct 2024
Association of COVID-19 with acute and post-acute risk of multiple different complications and mortality in patients infected with omicron variant stratified by initial disease severity: a cohort study in Hong Kong
- BMC Medicine

14 Oct 2024
Psychotropic drug prescribing before and during the COVID-19 pandemic among people with depressive and anxiety disorders: a multinational network study
- The Lancet Psychiatry

03 Sep 2024
Comparative effectiveness and safety of BNT162b2 and CoronaVac in Hong Kong: A target trial emulation
- International Journal of Infectious Diseases

01 Sep 2024
Comparing the effectiveness of molnupiravir and nirmatrelvir-ritonavir in non-hospitalized and hospitalized COVID-19 patients with type 2 diabetes: A target trial emulation study
- Diabetes Obesity and Metabolism

07 Aug 2024
Sex-specific comparative outcomes between oral anticoagulants in patients with atrial fibrillation: a systematic review and meta-analysis
- Open Heart

16 Jul 2024
Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy with remdesivir or nirmatrelvir–ritonavir in patients hospitalised with COVID-19: a target trial emulation study
- The Lancet Infectious Diseases

15 Jul 2024
Lithium and the risk of fractures in patients with bipolar disorder: A population-based cohort study
- Psychiatry Research

14 Jul 2024
Effectiveness of post-COVID-19 primary care attendance in improving survival in very old patients with multimorbidity: a territory-wide target trial emulation
- Family Medicine and Community Health

14 Jul 2024
Real-World Effectiveness and Safety of Tixagevimab-Cilgavimab: A Target Trial Emulation Study
- Drug Safety

25 Jun 2024
Unveiling unique clinical phenotypes of hip fracture patients and the temporal association with cardiovascular events
- Nature Communications

22 May 2024
Comparison of safety and efficacy between Nirmatrelvir-ritonavir and molnupiravir in the treatment of COVID-19 infection in patients with advanced kidney disease: a retrospective observational study
- eClinicalMedicine

05 May 2024
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother-child pairs
- Nature Medicine

08 Apr 2024
Low Bone Mineral Density as a Risk Factor for Liver Cirrhosis: A Prospective Cohort Study
- The Journal of Clinical Endocrinology & Metabolism

04 Apr 2024
Risks of incident major osteoporotic fractures following SARS-CoV-2 infection among older individuals: a population-based cohort study in Hong Kong
- Journal of Bone and Mineral Research

09 Mar 2024
Incidence of mental health diagnoses during the COVID-19 pandemic: a multinational network study
- Epidemiology and Psychiatric Sciences

04 Mar 2024
COVID-19 vaccine effectiveness against the Omicron variant of SARS-CoV-2 in multimorbidity: A territory-wide case-control study
- iScience

04 Mar 2024
Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease
- World Journal of Hepatology

27 Feb 2024
Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection
- Nature Communications

26 Feb 2024
Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in CKD Patients With COVID-19
- Kidney International Reports

09 Feb 2024
Effects of sequential vs single pneumococcal vaccination on cardiovascular diseases among older adults: a population-based cohort study
- International Journal of Epidemiology

08 Feb 2024
Vaccine Effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 Omicron BA.2 in CKD
- Clinical Journal of the American Society of Nephrology

26 Dec 2023
Cross-Regional Data Initiative for the Assessment and Development of Treatment for Neurological and Mental Disorders
- Clinical Epdemiology

21 Dec 2023
Effectiveness and Respiratory Adverse Events Following Inactivated and mRNA COVID-19 Vaccines in Patients with COPD and Asthma: A Chinese Population-Based Study
- Springer Link

12 Dec 2023
Risks of COVID-19-related hospitalisation and mortality among individuals with mental disorders following BNT162b2 and CoronaVac vaccinations: A case-control study
- Psychiatry Research

01 Nov 2023
Elevated risk of multimorbidity post-COVID-19 infection: protective effect of vaccination
- QJM: An International Journal of Medicine

12 Oct 2023
Association between cumulative exposure periods of flupentixol or any antipsychotics and risk of lung cancer
- Communication Medicine

17 Oct 2023
Long-term effects of coronavirus disease 2019 on diabetes complications and mortality in people with diabetes: Two cohorts in the UK and Hong Kong
- Diabetes, Obesity and Metabolism

21 Sep 2023
Effectiveness of molnupiravir vs nirmatrelvir-ritonavir in non-hospitalised and hospitalised patients with COVID-19: a target trial emulation study
- eClinicalMedicine

19 Sep 2023
Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study
- Cell Reports Medicine

15 Sep 2023
Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study
- Nature Communications

17 Aug 2023
Incidence of diabetes following COVID-19 vaccination and SARS-CoV-2 infection in Hong Kong: A population-based cohort study
- PLOS Medicine

24 Jul 2023
Waning effectiveness against COVID-19-related hospitalisation, severe complications, and mortality with two to three doses of CoronaVac and BNT162b2: a case-control study
- Emerging Microbes and Infections

18 May 2023
Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 omicron infection and related hospital admission among people with substance use disorder in Hong Kong: a matched case-control study
- The Lancet Psychiatry

01 May 2023
Effectiveness of BNT162b2 after extending the primary-series dosing interval in children and adolescents aged 5-17
- Nature Communications

03 Apr 2023
Effectiveness of Molnupiravir and Nirmatrelvir–Ritonavir in Hospitalized Patients With COVID-19
- Annals Of Internal Medicine

14 Mar 2023
Molnupiravir and nirmatrelvir–ritonavir reduce mortality risk during post-acute COVID-19 phase
- Journal of Infection

21 Feb 2023
Booster vaccination with inactivated whole-virus or mRNA vaccines and COVID-19–related deaths among people with multimorbidity: a cohort study
- Canadian Medical Association Journal

30 Jan 2023
Tuberculosis following two-dose SARS-CoV-2 vaccination with messenger RNA vaccine (BNT162b2) and inactivated virus vaccine (CoronaVac)
- Journal of Infection

16 Dec 2022
Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared With Viral Myocarditis
- Journal of the American College of Cardiology

13 Dec 2022
Risk of glomerular diseases, proteinuria and hematuria following mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines
- Nephrology Dialysis Transplantation

28 Oct 2022
Effectiveness of BNT162b2 and CoronaVac vaccinations against SARS-CoV-2 omicron infection in people aged 60 years or above: a case–control study
- Journal of Travel Medicine

17 Oct 2022
Risk of thyroid dysfunction associated with mRNA and inactivated COVID-19 vaccines: a population-based study of 2.3 million vaccine recipients
- BMC Medicine

14 Oct 2022
Association between the risk of seizure and COVID-19 vaccinations: A self-controlled case-series study
- Epilepsia

13 Oct 2022
Effectiveness of BNT162b2 and CoronaVac vaccinations against mortality and severe complications after SARS-CoV-2 Omicron BA.2 infection: a case-control study
- Emerging Microbes and Infections

18 Aug 2022
Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 Omicron BA.2 infection, hospitalisation, severe complications, cardiovascular disease and mortality in patients with diabetes mellitus: A case control study
- Journal of Infection

17 Aug 2022
The effectiveness and safety of mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines among individuals with chronic kidney diseases
- Kidney International

11 Aug 2022
Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines
- Journal of Hepatology

08 Jul 2022
Safety of an inactivated, whole-virion COVID-19 vaccine (CoronaVac) in people aged 60 years or older in Hong Kong: a modified self-controlled case series
- Lancet Healthy Longevity

01 Jul 2022
Association between BNT162b2 or CoronaVac COVID-19 vaccines and major adverse cardiovascular events among individuals with cardiovascular disease
- Cardiovascular Research

22 Jun 2022
Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination With BNT162b2 Increased Risk of Bell’s Palsy: A Nested Case-Control and Self-Controlled Case Series Study
- Clinical Infectious Diseases

08 Jun 2022
Safety of two-dose COVID-19 vaccination (BNT162b2 and CoronaVac) in adults with cancer: a territory-wide cohort study
- Journal of Hematology & Oncology

19 May 2022
Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: A descriptive cohort study among 1.1 million vaccinated people in Hong Kong
- Journal of Autoimmunity

14 Apr 2022
Adverse Events of Special Interest Following the Use of BNT162b2 in Adolescents: A Population-Based Retrospective Cohort Study
- Emerging Microbes & Infections

21 Mar 2022
Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization
- BMC Medicine

17 Mar 2022
Mortality-causing mechanisms and healthcare resource utilisation of treatment-resistant depression: A six-year population-based cohort study
- The Lancet Regional Health: Western Pacific

15 Mar 2022
Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong
- JAMA Pediatrics

25 Feb 2022
Lack of inflammatory bowel disease flare-up following two-dose BNT162b2 vaccine: a population-based cohort study
- Gut

08 Feb 2022
Herpes zoster related hospitalization after inactivated (CoronaVac) and mRNA (BNT162b2) SARS-CoV-2 vaccination: A self-controlled case series and nested case-control study (jointly published by Programme 1 & 4)
- The Lancet Regional Health, Western Pacific

01 Feb 2022
COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study
- American Journal of Hematology

26 Jan 2022
Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong
- Nature Communications

20 Jan 2022
Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong
- The BMJ: Annals of the Rheumatic Diseases

22 Oct 2021
Bell’s palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study
- The Lancet Infectious Diseases

16 Aug 2021

Programme 5

AI-Assisted Scalable Data Analytics for Global Health Protection

Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas
- Nature Medicine

18 Jun 2024
Diagnostic accuracy of artificial intelligence assisted clinical imaging in the detection of oral potentially malignant disorders and oral cancer: a systematic review and meta-analysis
- International Journal of Surgery

23 Apr 2024
MetaQuad: shared informative variants discovery in metagenomic samples
- Bioinformatics Advances

24 Feb 2024
Construction and optimization of multi-platform precision pathways for precision medicine
- Scientific Reports

21 Feb 2024
The Effect of the COVID-19 Pandemic on Non–COVID-19 Deaths: Population-Wide Retrospective Cohort Study
- JMIR Public Health and Surveillance

13 Feb 2024
scDecouple: decoupling cellular response from infected proportion bias in scCRISPR-seq
- Briefings in Bioinformatics

06 Feb 2024
In vitro and in vivo models define a molecular signature reference for human embryonic notochordal cells
- iScience

25 Jan 2024
A single-cell atlas of conventional central chondrosarcoma reveals the role of endoplasmic reticulum stress in malignant transformation
- Communications Biology

24 Jan 2024
BIDCell: Biologically-informed self-supervised learning for segmentation of subcellular spatial transcriptomics data
- Nature Communications

13 Jan 2024
Vulture: cloud-enabled scalable mining of microbial reads in public scRNA-seq data
- GigaScience

09 Jan 2024
Data integration and inference of gene regulation using single-cell temporal multimodal data with scTIE
- Genome Research

15 Dec 2023
Robust variable selection under cellwise contamination
- Journal of Statistical Computation and Simulation

28 Nov 2023
Discovery of regulatory motifs in 5' untranslated regions using interpretable multi-task learning models
- Cell Systems

27 Nov 2023
An edge-device-compatible algorithm for valvular heart diseases screening using phonocardiogram signals with a lightweight convolutional neural network and self-supervised learning
- Computer Methods and Programs in Biomedicine

04 Nov 2023
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
- Cell Reports

10 Aug 2023
Atlas-scale single-cell multi-sample multi-condition data integration using scMerge2
- Nature Communications

17 Jul 2023
DCATS: differential composition analysis for flexible single-cell experimental designs
- Genome Biology

26 Jun 2023
Ensemble deep learning of embeddings for clustering multimodal single-cell omics data
- Bioinformatics

14 Jun 2023
Lipidomics Profiling and Risk of Coronary Artery Disease in the BioHEART-CT Discovery Cohort
- Biomolecules

31 May 2023
Association of Molnupiravir and Nirmatrelvir-Ritonavir with reduced mortality and sepsis in hospitalized omicron patients: a territory-wide study
- Scientific Reports

15 May 2023
Integrative processing of untargeted metabolomic and lipidomic data using MultiABLER
- iScience

13 May 2023
Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity
- Nucleic Acids Research

01 May 2023
Benchmarking of analytical combinations for COVID-19 outcome prediction using single-cell RNA sequencing data
- Briefings in Bioinformatics

24 Apr 2023
Sex Differences in Association Between Gut Microbiome and Essential Hypertension Based on Ambulatory Blood Pressure Monitoring
- Hypertension

19 Apr 2023
Overcoming cohort heterogeneity for the prediction of subclinical cardiovascular disease risk
- iScience

11 Apr 2023
Translation Rate Prediction and Regulatory Motif Discovery with Multi-task Learning
- Research in Computational Molecular Biology

03 Apr 2023
NEMoE: a nutrition aware regularized mixture of experts model to identify heterogeneous diet-microbiome-host health interactions
- Microbiome

15 Mar 2023
Thinking process templates for constructing data stories with SCDNEY
- F1000Research

10 Mar 2023
StarmapVis: An interactive and narrative visualisation tool for single-cell and spatial data
- Computational and Structural Biotechnology Journal

13 Feb 2023
Deep multimodal graph-based network for survival prediction from highly multiplexed images and patient variables
- Computers in Biology and Medicine

01 Feb 2023
Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet
- Microbiome

04 Nov 2022
Incidence of Emergency Department Visits for Sexual Abuse Among Youth in Hong Kong Before and During the COVID-19 Pandemic
- JAMA Network Open

20 Oct 2022
Association of Molnupiravir and Nirmatrelvir-Ritonavir with preventable mortality, hospital admissions and related avoidable healthcare system cost among high-risk patients with mild to moderate COVID-19
- The Lancet Regional Health

04 Oct 2022
An artificial intelligence-enabled smartphone app for real-time pressure injury assessment
- Frontiers in Medical Technology

23 Sep 2022
Molecular determinants of intrinsic cellular stiffness in health and disease
- Biophysical Reviews

21 Sep 2022
Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities
- Nature Communications

25 Apr 2022
MQuad enables clonal substructure discovery using single cell mitochondrial variants
- Nature Communications

08 Mar 2022
Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression
- Gut

29 Sep 2021
Generalized and scalable trajectory inference in single-cell omics data with VIA
- Nature Communications

20 Sep 2021
Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q
- Redox Biology

08 Sep 2021
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma
- JAMA Otolaryngology–Head & Neck Surgery

19 Aug 2021
FlowGrid enables fast clustering of very large single-cell RNA-seq data
- Bioinformatics

21 Jul 2021
The method to quantify cell elasticity based on the precise measurement of pressure inducing cell deformation in microfluidic channels
- MethodsX

23 Jan 2021